Genetic diseases impact on fertility

Certain inherited diseases can interfere with getting pregnant. You may already know you have an infertility-causing disease, , or may you just find out when you start trying to get pregnant.
Genetic diseases such as Turner Syndrome in women, Kleinfelter Syndrome in men and cystic fibrosis can cause infertility. Less easily recognized problems, such as deletion of part of the Y chromosome in males, may not be recognized until a fertility workup is done.
About 1 in 500 people has a chromosomal translocation. Translocation of chromosomes may cause an individual no problem and isn’t usually obvious but may cause recurrent miscarriage if passed on by either parent. This is because the translocation in an individual is usually balanced — one piece of a chromosome has been exchanged for another. When the chromosome is passed on, however, it may be “unbalanced,” causing miscarriage or abnormal pregnancy.